HealthLawProf Blog

Editor: Katharine Van Tassel
Concordia University School of Law

Thursday, October 7, 2010

SSRN Top Ten Health Law Downloads Between August 8 and October 7, 2010

The following are the top ten SSRN downloads for Health Law for the period between August 8 and October 7, 2010:

Rank Downloads Paper Title
1 78 Adverse Reactions: Structure, Philosophy, and Outcomes of the Patient Protection and Affordable Care Act
Michael Lee,
Yale University - Law School,
Date posted to database: July 15, 2010
Last Revised: July 15, 2010
2 70 A Sobering Conflict: A Call for Consistency in the Messages Colleges Send About Alcohol
Marc Edelman, David Rosenthal,
Barry Law School, Rutgers, The State University of New Jersey - School of Law-Camden,
Date posted to database: April 5, 2010
Last Revised: April 5, 2010
3 68 Kidneys, Cash & Kashrut: A Legal, Economic, and Religious Analysis of Selling Kidneys
Robert Steinbuch,
University of Arkansas at Little Rock,
Date posted to database: August 23, 2010
Last Revised: August 23, 2010
4 67 Waiving Your Privacy Goodbye: Privacy Waivers and the HITECH Act’s Regulated Price for Sale of Health Data to Researchers
Barbara J. Evans,
University of Houston - Law Center,
Date posted to database: August 24, 2010
Last Revised: August 24, 2010
5 66 When Do Generics Challenge Drug Patents?
C. Scott Hemphill, Bhaven N. Sampat,
Columbia University - Law School, Columbia University - Mailman School of Public Health,
Date posted to database: July 15, 2010
Last Revised: September 1, 2010
6 65 The Hollow Promise of Freedom of Conscience
Nadia N. Sawicki,
Loyola-Chicago School of Law, Beazley Institute for Health Law & Policy,
Date posted to database: August 28, 2010
Last Revised: October 6, 2010
7 64 Factual Causation and Asbestos Cancers
Jane Stapleton, Jane Stapleton,
Australian National University (ANU) - College of Law, University of Texas at Austin School of Law,
Date posted to database: July 31, 2010
Last Revised: July 31, 2010
8 60 Trading-Off Reproductive Technology and Adoption: Does Subsidizing in Vitro Fertilization Decrease Adoption Rates and Should it Matter?
I. Glenn Cohen, Daniel L. Chen,
Harvard Law School, Duke University - School of Law,
Date posted to database: August 24, 2010
Last Revised: August 24, 2010
9 56 Disability Rights and the Law of Welfare
Mark C. Weber,
DePaul University College of Law,
Date posted to database: August 19, 2010
Last Revised: August 19, 2010
10 51 New Horizons: Incorporating Socio-Economic Rights in a British Bill of Rights
Sandra Fredman,
University of Oxford Faculty of Law,
Date posted to database: June 28, 2010
Last Revised: July 4, 2010

October 7, 2010 | Permalink | Comments (0) | TrackBack (0)

Sunday, October 3, 2010

Scientists Discover Genes Related to Body Mass

Johns Hopkins scientists specializing in genetic information have discovered 13 genes linked to human body mass. The genes were identified by screening the epigenome and could provide information that can be used to prevent and treat obesity. The authors of the study explained how they discovered the genes and the implications of their discovery to Science Daily:

"Some of the genes we found are in regions of the genome previously suspected but not confirmed for a link to body mass index and obesity," says co-lead investigator Andrew Feinberg, M.D., M.P.H., King Fahd Professor of Molecular Medicine and director of the Center for Epigenetics at Johns Hopkins' Institute for Basic Biomedical Sciences. "Meanwhile, others were a surprise, such as one known to be associated with foraging behavior in hungry worms."

Starting with DNA samples extracted from Icelanders' white blood cells banked in 1991 and 2002 by scientists there as part of the AGES-Reykjavik study of individuals in the general population, the Hopkins team used a customized, genome-wide profiling method dubbed CHARM (comprehensive high-throughput arrays for relative methylation) to look for regions that were the most variable, all chemically marked by DNA methylation.

"Epigenetics has given us 13 exciting new leads to variability in body mass and obesity," says co-lead investigator M. Daniele Fallin, Ph.D., associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health. "The team's success suggests a new epigenetic strategy for identifying those at risk for many common diseases, and for possible new prevention methods and therapies."

Curious to know if these signatures were linked to obesity-related disease, the researchers analyzed them in relation to each person's body mass index -- a measure of one's weight relative to height. BMI was chosen, Feinberg says, because a high BMI predicts risk for many common diseases in the general population.

"What we accomplished is a small proof-of-principle study that we think is just the tip of the iceberg in using epigenetics to expand our knowledge of new markers for many common diseases and opening the door for personalized epigenetic medicine," Feinberg says.

"BMI is just a starting point for us," agrees Rafael Irizarry, Ph.D., a professor of biostatistics and co-author of the report. "We want to use the same method to look for genes associated with autism, bipolar disease and variations in aging."



October 3, 2010 | Permalink | Comments (0) | TrackBack (0)